Reviews of Physiology, Biochemistry and Pharmacology, Volume 84

Insulin--history, biochemistry, physiology and pharmacology.

The discovery of insulin was a seminal event in both the study of diabetes and the care of diabetic pa tients. The development of procedures for purifying and modifying insulin took an additional 30 years. In his masterful rendition of these developments, Mi chael Bliss recounts the remarkable story surrounding the discovery of insulin and notes that the discovery of insulin at the University o...

The Biochemistry and Physiology of Bone. Volume II

pressure, and temperature, illustrated by many interesting, but somewhat loosely arranged, examples. Unfortunately, the major part of this chapter deals with laboratory work, and we never really find out whether clinical counterparts exist. For example, it is fascinating to know that digitalis is more toxic at higher altitudes and when the barometer falls, but is the clinical incidence of digit...

Pesticide Biochemistry and Physiology

Type-II pyrethroids, including deltamethrin, are highly toxic to Paramecium tetraurelia, an organism that does not possess a voltage-sensitive sodium channel. Previous research has established that deltamethrin is toxic to P. tetraurelia in mortality bioassays at concentrations as low as 10210 and 10211 M under resting and depolarizing conditions, respectively. Deltamethrin, likewise, stimulate...

Platelets: physiology and biochemistry.

Platelets are specialized blood cells that play central roles in physiologic and pathologic processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense. Activation of platelets is crucial for platelet function that includes a complex interplay of adhesion and signaling molecules. This article gives an overview of the activation processes involved in primary and seco...

Microbial Physiology and Biochemistry